Attending the meeting in person will not in and of itself revoke a previously submitted proxy unless you specifically request it. Your most current vote, whether by telephone, Internet or proxy card, is the one that will be counted. You may receive more than one Notice or proxy card if you hold shares of our common stock in more than one account, which may be in registered form or held in street name.
In the description, the following terms are employed. A disc surface, according to this invention, can be an internal or external surface. Nonoperational structures and investigational features include, for example, analyte-specific signal elements, as described immediately below.
The term thus includes, inter alia, such signal elements as are exemplified herein—including beads—as well as those that are described in copending and commonly owned U. The term includes both those structures that are alone detectable by an optical disc reader and those that require additional components to be rendered detectable.
Copending and commonly owned U. During trackable reading of these novel discs, the, nonoperational structures produce signals that are discriminably embedded within the normal operational electrical responses; the embedded signals report physical properties of the nonoperational structures.
Using such discs, the routine process of optical disc reading is transformed into a scanning laser microscopic inspection of one or more of the disc's surfaces, and the disc drive into a scanning confocal laser microscope.
The signals generated by the nonoperational structures, however, match no established optical disc data encoding standard. The nonoperational structures exemplified in copending and commonly owned U.
Although the outer diameter of the spheres used in the examples of this invention is typically on the order of microns i.
The protean nature of such structures—the extraordinary range in permissible size, reflectivity, absorbence, and shape—creates an enormous diversity in resulting signal patterns. Furthermore, such nonoperational structures will often be stochastically, rather than determinatively, distributed on the surface of the disc; the location of the relevant signal patterns will often not be known in advance.
There thus exists a need in the art for analytical methods, software, and devices that can recognize, discriminate, and classify a wide variety of patterns distributed randomly throughout the digital data sample.
Many of the nonoperational structures to be detected by optical inspection of such discs will be sufficiently large as to cross at least two adjacent tracks, producing patterns discontinuously in the digital data stream.
In this, case, the discontinuity in the data between the two data features can report a physical property of the structure in the tangential direction. Notwithstanding existing deinterleaving algorithms, no optical disc decoding scheme has contemplated assembling discontinuous data according to the tangential locality of the data on the physical disc surface.
Accordingly, there exists a need for methods and apparatus for effecting such decoding of data.
More generally, the physical location of digitally-encoded data on optical discs is of significance under existing standards principally as it affects the operational necessities of the reading process, and in particular, as it implicates access to the data during reading.
Once the data are read and decoded, the physical location that the data had occupied on the disc becomes irrelevant: In contrast, the use of an optical disc reader as a scanning laser confocal microscope can make the original physical location of detected structures of enduring relevance during analysis.
For example, as noted above, the physical location of one or more detected structures can be used to identify radial and tangential dimensions of the underlying structure.
Additionally, the physical location of the detected structure is relevant to the analysis and interpretation of analyte-specific assays that are disposed on the disc in deliberate geometric patterns.
There thus exists a need for methods and apparatus for mapping data patterns produced by one or more nonoperational structures e. The present invention solves these and other problems in the art by presenting methods and apparatus for analyzing nonoperational data acquired from optical discs.
The methods and apparatus are particularly useful in analyzing nonoperational data acquired from trackable optical discs having concurrently readable nonoperational structures. In step 11, program parameters are initialized. As used herein, program parameters include, but are not limited to, memory allocation parameters, form parameters, which are used in the program's graphical user interface e.
In an embedded, real-time form of this invention, the overall environment could also be initialized. Various result object types, which are discussed below, may be used by one or more including all program forms according to this invention.
Program parameter initialization is optional and its necessity may depend on the particular programming environment used to implement this invention. After initialization, data are retrieved from a data source in step A data source can either be specified by a user or defined by the program itself.
A data source according to this invention can be direct data source 12, which may provide a substantially continuous data stream, or stored data source 17, which may provide a previously stored data file. Direct data source 12 can be a local or remote optical disc drive i.
If remote, direct data source 12 can be connected to a computer programmed according to this invention via the Internet or any other network-type connection.
Direct data can also be provided through an auxiliary device connected to a drivesuch as a conventional analog-to-digital converter, or a customized equivalent thereof.
A computer programmed to retrieve direct data in step 13 could be synchronized with a computer programmed to acquire data.
An example of how data can be acquired and retrieved according to this invention is described in U. In order to selectively acquire data from any portion of an optical disc e.Nanogene Solutions Sdn Bhd was set up as a solution provider for Life Science and Biotechnology.
Ocean Ridge Biosciences (ORB) is a profitable South Florida-based laboratory contract research organization (CRO) providing innovative RNA Profiling and Biomarker Discovery services to Drug Discovery and Drug Development researchers.
Volume 9, Issue 1 January/February NEWSLETTER Mission Statement: The Association for Women in Science, Inc. (AWIS) is a non-profit organization dedicated to the achievement of.
NANOGEN BIOPHARMACEUTICAL is a leading company that is doing research and development of active Biopharmaceutical ingredients (APIs), and specific therapeutic injections in Asia Pacific region, based on advance in recombinant DNA and protein technologies.
US companies Nanogen, a developer of advanced in vitro diagnosticproducts, and Epoch Biosciences, a provider To continue reading The Pharma Letter please login, subscribe or claim a 7 day free trial subscription and access exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space.
Nanogen also offers a broad portfolio of patented nucleic acids chemistries and molecular tools that accelerate genomic analysis and are compatible with many systems.